2006 Heart-Brain summit proceedings
New paradigms in heart-brain medicine: Nonlinear physiology, state-dependent proteomics
ARTICLE INTRODUCTION
Two pivotal studies using a conscious pig model of heart attack suggest new paradigms for the discovery of cardiac devices and drugs. The first study showed that nonlinear analysis of heartbeat intervals, which are controlled by the nervous system, could predict with high sensitivity and specificity whether or not ventricular fibrillation (VF) would later occur following occlusion (90% reduction of blood flow by pulsed-Doppler recording) of the left anterior descending coronary artery. This predictive ability was later confirmed by retrospective data from humans exhibiting coronary artery narrowing and nonsustained ventricular tachycardia. The second pivotal study showed that the state-dependent release of a salutary molecule during rapid eye movement (REM) sleep would suppress arrhythmogenesis in the acutely infarcted heart. It is presumed that neurosecretion explains the salutary effect, as the latency is on the order of seconds.
This article reports previously patented data from additional investigations by me and my colleagues to further explore these two new paradigms in heart-brain medicine. First I review results from a prospective multicenter study of heartbeat analysis using a nonlinear algorithm to predict future arrhythmic death in emergency room patients. Then I discuss insights from state-dependent proteomics in the hibernating woodchuck and resulting efforts to isolate, identify, and synthesize an anti-infarction molecule from the woodchuck and test its efficacy using bioassay models.
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