2007 Heart-Brain summit proceedings
Depression and coronary heart disease: Association and implications for treatment
ABSTRACT
Growing evidence indicates that depression is an important primary and secondary risk factor for coronary heart disease (CHD). Depression is quite common among patients with CHD: prevalence estimates are 14% or higher, and an additional 20% of patients have subclinical or minor depression. This review summarizes evidence that depression is a risk factor for cardiac events in patients with established CHD, suggests potential mechanisms underlying the relationship between depression and adverse cardiac outcomes, and provides evidence for the efficacy of exercise in improving both depression and clinical outcomes in depressed patients with CHD.
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DEPRESSION AND CORONARY DISEASE
FIGURE 4. Predicted survival functions for patients who did (n =
952) and did not (n = 1,096) exercise regularly during the 6 months
following an index myocardial infarction in the ENRICHD trial. There
were a total of 187 fatal events; the mortality rate was 5.7% among
the exercisers compared with 12.0% among the nonexercisers.52
Reprinted, with permission, from Blumenthal JA, et al. Exercise, depression, and mortality
after myocardial infarction in the ENRICHD trial. Med Sci Sports Exerc 2004; 36:746–755.
1.00
0.95
0.90
0.85
0.80
0.75
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0 6 12 18 24 30 36 42
Follow-up time (months)
Survival rate
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