2006 Heart-Brain summit proceedings
Cardiac denervation in patients with Parkinson disease
ARTICLE INTRODUCTION
Until relatively recently, Parkinson disease (PD) was viewed as mainly a movement disorder, resulting from loss of nigrostriatal dopamine terminals in the brain. Almost all patients with PD, however, have symptoms or signs ofdysfunction of the autonomic nervous system, such as constipation, urinary incontinence, orthostatic or postprandial light-headedness, heat or cold intolerance, and orthostatic hypotension. Recent studies focusing on the sympathetic noradrenergic component of the autonomic nervous system have supported the concept that PD is not only a movement disorder but also a form of dysautonomia. This review provides an update on the status of the innervation of the heart in PD.
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